Relation Between Aspirin Dose, All-Cause Mortality, and Bleeding in Patients With Recent Cerebrovascular or Coronary Ischemic Events (from the BRAVO Trial)
Identifieur interne : 008A85 ( Main/Exploration ); précédent : 008A84; suivant : 008A86Relation Between Aspirin Dose, All-Cause Mortality, and Bleeding in Patients With Recent Cerebrovascular or Coronary Ischemic Events (from the BRAVO Trial)
Auteurs : Herbert D. Aronow [États-Unis] ; Robert M. Califf [États-Unis] ; Robert A. Harrington [États-Unis] ; Marc Vallee [États-Unis] ; Carmelo Graffagnino [États-Unis] ; Ashfaq Shuaib [Canada] ; Desmond J. Fitzgerald [Irlande (pays)] ; J. Donald Easton [États-Unis] ; Frans Van De Werf [Belgique] ; Hans-Christoph Diener [Allemagne] ; James Ferguson [États-Unis] ; Peter J. Koudstaal [Pays-Bas] ; Pierre Amarenco [France] ; Pierre Theroux [Canada] ; Stephen Davis [Australie] ; Eric J. Topol [États-Unis]Source :
- The American journal of cardiology [ 0002-9149 ] ; 2008.
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Abstract
Despite aspirin's established role in the treatment of atherosclerotic vascular disease, considerable controversy exists regarding its most effective dosing strategy. In a retrospective observational study, we examined the relation between prescribed aspirin dose (<162 mg vs ≥162 mg/day aspirin) and clinical outcome in 4,589 placebo-treated patients enrolled in the Blockage of the Glycoprotein IIb/IIIa Receptor to Avoid Vascular Occlusion (BRAVO) trial over a median follow-up of 366 days. Standard Cox regression analysis was employed because propensity analysis was not feasible. Compared with lower aspirin doses, higher doses were associated with lower unadjusted all-cause mortality (2.9 vs 1.6%, respectively; log rank chi-square 8.6, p = 0.0034). Higher aspirin dose remained independently predictive of lower all-cause mortality in a multivariable Cox proportional hazards model (hazard ratio 0.64, 95% confidence interval 0.42 to 0.97, p = 0.037). However, there was no significant difference in the incidence of the composite endpoint death, nonfatal myocardial infarction, or nonfatal stroke (6.1% vs 6.2%, p = 0.74). Higher aspirin dose was a significant independent predictor of any (hazard ratio 1.32, 95% confidence interval 1.12 to 1.55, p = 0.001) but not serious bleeding. In conclusion, our findings suggest that aspirin doses of ≥ 162 mg/day may be more beneficial than those <162 mg/day at preventing death.
Affiliations:
- Allemagne, Australie, Belgique, Canada, France, Irlande (pays), Pays-Bas, États-Unis
- Californie, Caroline du Nord, Hollande-Méridionale, Michigan, Québec, Rhode Island, Texas, Victoria (État), Île-de-France
- Melbourne, Montréal, Paris, Rotterdam
- Université de Melbourne
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Relation Between Aspirin Dose, All-Cause Mortality, and Bleeding in Patients With Recent Cerebrovascular or Coronary Ischemic Events (from the BRAVO Trial)</title><author><name sortKey="Aronow, Herbert D" sort="Aronow, Herbert D" uniqKey="Aronow H" first="Herbert D." last="Aronow">Herbert D. Aronow</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Clinical Scholars Program, Michigan Heart and Vascular Institute at St. Joseph Mercy Hospital</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Califf, Robert M" sort="Califf, Robert M" uniqKey="Califf R" first="Robert M." last="Califf">Robert M. Califf</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Duke Clinical Research Institute, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Harrington, Robert A" sort="Harrington, Robert A" uniqKey="Harrington R" first="Robert A." last="Harrington">Robert A. Harrington</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Duke Clinical Research Institute, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vallee, Marc" sort="Vallee, Marc" uniqKey="Vallee M" first="Marc" last="Vallee">Marc Vallee</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Duke Clinical Research Institute, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Graffagnino, Carmelo" sort="Graffagnino, Carmelo" uniqKey="Graffagnino C" first="Carmelo" last="Graffagnino">Carmelo Graffagnino</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Division of Neurology, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Shuaib, Ashfaq" sort="Shuaib, Ashfaq" uniqKey="Shuaib A" first="Ashfaq" last="Shuaib">Ashfaq Shuaib</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Fitzgerald, Desmond J" sort="Fitzgerald, Desmond J" uniqKey="Fitzgerald D" first="Desmond J." last="Fitzgerald">Desmond J. 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Donald Easton</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Rhode Island Hospital and Brown University</s1><s2>Providence, Rhode Island</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Rhode Island</region></placeName></affiliation></author><author><name sortKey="Van De Werf, Frans" sort="Van De Werf, Frans" uniqKey="Van De Werf F" first="Frans" last="Van De Werf">Frans Van De Werf</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Cardiology, University Hospital Gasthuisberg</s1><s2>Leuven</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology University Duisburg-Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Department of Neurology University Duisburg-Essen</wicri:noRegion><wicri:noRegion>Department of Neurology University Duisburg-Essen</wicri:noRegion></affiliation></author><author><name sortKey="Ferguson, James" sort="Ferguson, James" uniqKey="Ferguson J" first="James" last="Ferguson">James Ferguson</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Texas Heart Institute at St Luke's Episcopal Hospital</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Koudstaal, Peter J" sort="Koudstaal, Peter J" uniqKey="Koudstaal P" first="Peter J." last="Koudstaal">Peter J. Koudstaal</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Neurology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>12 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology and Stroke Center, Bichat University Hospital, Denis Diderot University and Medical School</s1><s2>Paris</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Montreal Heart Institute and University of Montreal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Davis, Stephen" sort="Davis, Stephen" uniqKey="Davis S" first="Stephen" last="Davis">Stephen Davis</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Division of Neurology, Royal Melbourne Hospital, University of Melbourne</s1><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Topol, Eric J" sort="Topol, Eric J" uniqKey="Topol E" first="Eric J." last="Topol">Eric J. Topol</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Division of Cardiovascular Diseases, Scripps Clinic</s1><s2>La Jolla, California</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0037296</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 09-0037296 INIST</idno><idno type="RBID">Pascal:09-0037296</idno><idno type="wicri:Area/PascalFrancis/Corpus">003071</idno><idno type="wicri:Area/PascalFrancis/Curation">002F46</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002F56</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002F56</idno><idno type="wicri:doubleKey">0002-9149:2008:Aronow H:relation:between:aspirin</idno><idno type="wicri:Area/Main/Merge">009370</idno><idno type="wicri:Area/Main/Curation">008A85</idno><idno type="wicri:Area/Main/Exploration">008A85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Relation Between Aspirin Dose, All-Cause Mortality, and Bleeding in Patients With Recent Cerebrovascular or Coronary Ischemic Events (from the BRAVO Trial)</title><author><name sortKey="Aronow, Herbert D" sort="Aronow, Herbert D" uniqKey="Aronow H" first="Herbert D." last="Aronow">Herbert D. Aronow</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Clinical Scholars Program, Michigan Heart and Vascular Institute at St. Joseph Mercy Hospital</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Califf, Robert M" sort="Califf, Robert M" uniqKey="Califf R" first="Robert M." last="Califf">Robert M. Califf</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Duke Clinical Research Institute, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Harrington, Robert A" sort="Harrington, Robert A" uniqKey="Harrington R" first="Robert A." last="Harrington">Robert A. Harrington</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Duke Clinical Research Institute, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vallee, Marc" sort="Vallee, Marc" uniqKey="Vallee M" first="Marc" last="Vallee">Marc Vallee</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Duke Clinical Research Institute, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Graffagnino, Carmelo" sort="Graffagnino, Carmelo" uniqKey="Graffagnino C" first="Carmelo" last="Graffagnino">Carmelo Graffagnino</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Division of Neurology, Duke University</s1><s2>Durham, North Carolina</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Shuaib, Ashfaq" sort="Shuaib, Ashfaq" uniqKey="Shuaib A" first="Ashfaq" last="Shuaib">Ashfaq Shuaib</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Neurology, University of Alberta</s1><s2>Edmonton</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Fitzgerald, Desmond J" sort="Fitzgerald, Desmond J" uniqKey="Fitzgerald D" first="Desmond J." last="Fitzgerald">Desmond J. Fitzgerald</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Clinical Pharmacology, Royal College of Surgeons in Ireland</s1><s2>Dublin</s2><s3>IRL</s3><sZ>7 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Easton, J Donald" sort="Easton, J Donald" uniqKey="Easton J" first="J. Donald" last="Easton">J. Donald Easton</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Rhode Island Hospital and Brown University</s1><s2>Providence, Rhode Island</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Rhode Island</region></placeName></affiliation></author><author><name sortKey="Van De Werf, Frans" sort="Van De Werf, Frans" uniqKey="Van De Werf F" first="Frans" last="Van De Werf">Frans Van De Werf</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Cardiology, University Hospital Gasthuisberg</s1><s2>Leuven</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology University Duisburg-Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Department of Neurology University Duisburg-Essen</wicri:noRegion><wicri:noRegion>Department of Neurology University Duisburg-Essen</wicri:noRegion></affiliation></author><author><name sortKey="Ferguson, James" sort="Ferguson, James" uniqKey="Ferguson J" first="James" last="Ferguson">James Ferguson</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Texas Heart Institute at St Luke's Episcopal Hospital</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Koudstaal, Peter J" sort="Koudstaal, Peter J" uniqKey="Koudstaal P" first="Peter J." last="Koudstaal">Peter J. Koudstaal</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Neurology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>12 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Neurology and Stroke Center, Bichat University Hospital, Denis Diderot University and Medical School</s1><s2>Paris</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Montreal Heart Institute and University of Montreal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>14 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Davis, Stephen" sort="Davis, Stephen" uniqKey="Davis S" first="Stephen" last="Davis">Stephen Davis</name><affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Division of Neurology, Royal Melbourne Hospital, University of Melbourne</s1><s3>AUS</s3><sZ>15 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Topol, Eric J" sort="Topol, Eric J" uniqKey="Topol E" first="Eric J." last="Topol">Eric J. Topol</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Division of Cardiovascular Diseases, Scripps Clinic</s1><s2>La Jolla, California</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The American journal of cardiology</title><title level="j" type="abbreviated">Am. j. cardiol.</title><idno type="ISSN">0002-9149</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of cardiology</title><title level="j" type="abbreviated">Am. j. cardiol.</title><idno type="ISSN">0002-9149</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylsalicylic acid</term><term>Cardiology</term><term>Cause</term><term>Circulatory system</term><term>Coronary artery</term><term>Coronary heart disease</term><term>Dose</term><term>Epidemiology</term><term>Hemorrhage</term><term>Human</term><term>Ischemia</term><term>Mortality</term><term>Posology</term><term>Prognosis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hémorragie</term><term>Cardiopathie coronaire</term><term>Ischémie</term><term>Acide acétylsalicylique</term><term>Dose</term><term>Posologie</term><term>Cause</term><term>Mortalité</term><term>Pronostic</term><term>Epidémiologie</term><term>Homme</term><term>Artère coronaire</term><term>Appareil circulatoire</term><term>Cardiologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite aspirin's established role in the treatment of atherosclerotic vascular disease, considerable controversy exists regarding its most effective dosing strategy. In a retrospective observational study, we examined the relation between prescribed aspirin dose (<162 mg vs ≥162 mg/day aspirin) and clinical outcome in 4,589 placebo-treated patients enrolled in the Blockage of the Glycoprotein IIb/IIIa Receptor to Avoid Vascular Occlusion (BRAVO) trial over a median follow-up of 366 days. Standard Cox regression analysis was employed because propensity analysis was not feasible. Compared with lower aspirin doses, higher doses were associated with lower unadjusted all-cause mortality (2.9 vs 1.6%, respectively; log rank chi-square 8.6, p = 0.0034). Higher aspirin dose remained independently predictive of lower all-cause mortality in a multivariable Cox proportional hazards model (hazard ratio 0.64, 95% confidence interval 0.42 to 0.97, p = 0.037). However, there was no significant difference in the incidence of the composite endpoint death, nonfatal myocardial infarction, or nonfatal stroke (6.1% vs 6.2%, p = 0.74). Higher aspirin dose was a significant independent predictor of any (hazard ratio 1.32, 95% confidence interval 1.12 to 1.55, p = 0.001) but not serious bleeding. In conclusion, our findings suggest that aspirin doses of ≥ 162 mg/day may be more beneficial than those <162 mg/day at preventing death.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Irlande (pays)</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Nord</li><li>Hollande-Méridionale</li><li>Michigan</li><li>Québec</li><li>Rhode Island</li><li>Texas</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Montréal</li><li>Paris</li><li>Rotterdam</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Aronow, Herbert D" sort="Aronow, Herbert D" uniqKey="Aronow H" first="Herbert D." last="Aronow">Herbert D. Aronow</name></region><name sortKey="Califf, Robert M" sort="Califf, Robert M" uniqKey="Califf R" first="Robert M." last="Califf">Robert M. Califf</name><name sortKey="Easton, J Donald" sort="Easton, J Donald" uniqKey="Easton J" first="J. Donald" last="Easton">J. Donald Easton</name><name sortKey="Ferguson, James" sort="Ferguson, James" uniqKey="Ferguson J" first="James" last="Ferguson">James Ferguson</name><name sortKey="Graffagnino, Carmelo" sort="Graffagnino, Carmelo" uniqKey="Graffagnino C" first="Carmelo" last="Graffagnino">Carmelo Graffagnino</name><name sortKey="Harrington, Robert A" sort="Harrington, Robert A" uniqKey="Harrington R" first="Robert A." last="Harrington">Robert A. Harrington</name><name sortKey="Topol, Eric J" sort="Topol, Eric J" uniqKey="Topol E" first="Eric J." last="Topol">Eric J. Topol</name><name sortKey="Vallee, Marc" sort="Vallee, Marc" uniqKey="Vallee M" first="Marc" last="Vallee">Marc Vallee</name></country><country name="Canada"><noRegion><name sortKey="Shuaib, Ashfaq" sort="Shuaib, Ashfaq" uniqKey="Shuaib A" first="Ashfaq" last="Shuaib">Ashfaq Shuaib</name></noRegion><name sortKey="Theroux, Pierre" sort="Theroux, Pierre" uniqKey="Theroux P" first="Pierre" last="Theroux">Pierre Theroux</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Fitzgerald, Desmond J" sort="Fitzgerald, Desmond J" uniqKey="Fitzgerald D" first="Desmond J." last="Fitzgerald">Desmond J. Fitzgerald</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Van De Werf, Frans" sort="Van De Werf, Frans" uniqKey="Van De Werf F" first="Frans" last="Van De Werf">Frans Van De Werf</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Diener, Hans Christoph" sort="Diener, Hans Christoph" uniqKey="Diener H" first="Hans-Christoph" last="Diener">Hans-Christoph Diener</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Koudstaal, Peter J" sort="Koudstaal, Peter J" uniqKey="Koudstaal P" first="Peter J." last="Koudstaal">Peter J. Koudstaal</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Davis, Stephen" sort="Davis, Stephen" uniqKey="Davis S" first="Stephen" last="Davis">Stephen Davis</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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